ABSTRACT
The development of a baboon model of induced endometriosis, which recapitulates the
retrograde menstruation hypothesis, has greatly facilitated our understanding of the
early events associated with the disease process. Sequential analysis of the eutopic
endometrium following the establishment of disease suggests that the development of
progesterone resistance is a gradual process and becomes evident after 6 months of
disease induction. This resistance is manifested by a decreased responsiveness of
the progesterone receptor and its chaperone immunophilins as well as epigenetic modifications
of progesterone-regulated genes. In comparative studies, the time-dependent changes
observed in the baboon eutopic endometrium are similar to those that have been reported
to be altered in women with endometriosis. The baboon model therefore provides insight
into the potential mechanisms by which genes in the eutopic endometrium are dysregulated
and how this alteration results in infertility that is associated with endometriosis.
KEYWORDS
Baboon - endometriosis - infertility - progesterone resistance
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Asgerally T FazleabasPh.D.
Professor and Associate Chair, Dept. of OB/GYN and Reprod Bio, College of Human Medicine,
Michigan State University
234 Division Ave N, Suite 410, Grand Rapids, MI 49503
Email: ASGI@HC.MSU.EDU
